Research: Aerobic Exercise Reverses Arterial Inflammation with Aging mice

Am J Physiol Heart Circ Physiol. 2011 May 27. [Epub ahead of print]

Aerobic Exercise Reverses Arterial Inflammation with Aging in Mice.

Source

1University of Utah.

Abstract

We tested the hypothesis that regular aerobic exercise reverses arterial inflammation with aging. Compared with young controls (6.3 ± 0.4 mo, n=7), old (31.3 ± 0.5 mo, n=11), male B6D2F1 cage-restricted mice demonstrated increased arterial activation of the pro-inflammatory transcription factor, nuclear factor κB (NFκB), as indicated by greater aortic phosphorylation of both the inhibitor of NFκB kinase (IKK) and the p65 subunit of NFκB (both P<0.05). Similarly, aortic expression of the pro-inflammatory cytokines interleukin-1 and -6, interferon γ and tumor necrosis factor α were greater in the old mice (all P<0.05). Macrophage and T lymphocyte abundance was unchanged with age in the aortic intima and media, but was markedly increased in the adventitia and perivascular fat tissue of old mice (all P<0.05). This pro-inflammatory arterial phenotype with aging was associated with vascular endothelial dysfunction, as reflected by impaired nitric oxide-mediated endothelium-dependent dilation (EDD). Voluntary wheel running (10-14 weeks) in old mice (32.4 ± 0.3 mo, n=9) normalized aortic IKK-NFκB activation, cytokine expression, adventitial and perivascular macrophage infiltration and endothelial function. Short-term voluntary wheel running started late in life reverses arterial inflammation with aging in mice possibly via “outside-in” actions. These anti-inflammatory effects may play an important role in the amelioration of age-associated vascular dysfunction by regular aerobic exercise.

PMID:
21622824
[PubMed – as supplied by publisher]