Research: Aerobic Exercise Reverses Arterial Inflammation with Aging mice

Am J Physiol Heart Circ Physiol. 2011 May 27. [Epub ahead of print]

Aerobic Exercise Reverses Arterial Inflammation with Aging in Mice.


1University of Utah.


We tested the hypothesis that regular aerobic exercise reverses arterial inflammation with aging. Compared with young controls (6.3 ± 0.4 mo, n=7), old (31.3 ± 0.5 mo, n=11), male B6D2F1 cage-restricted mice demonstrated increased arterial activation of the pro-inflammatory transcription factor, nuclear factor κB (NFκB), as indicated by greater aortic phosphorylation of both the inhibitor of NFκB kinase (IKK) and the p65 subunit of NFκB (both P<0.05). Similarly, aortic expression of the pro-inflammatory cytokines interleukin-1 and -6, interferon γ and tumor necrosis factor α were greater in the old mice (all P<0.05). Macrophage and T lymphocyte abundance was unchanged with age in the aortic intima and media, but was markedly increased in the adventitia and perivascular fat tissue of old mice (all P<0.05). This pro-inflammatory arterial phenotype with aging was associated with vascular endothelial dysfunction, as reflected by impaired nitric oxide-mediated endothelium-dependent dilation (EDD). Voluntary wheel running (10-14 weeks) in old mice (32.4 ± 0.3 mo, n=9) normalized aortic IKK-NFκB activation, cytokine expression, adventitial and perivascular macrophage infiltration and endothelial function. Short-term voluntary wheel running started late in life reverses arterial inflammation with aging in mice possibly via “outside-in” actions. These anti-inflammatory effects may play an important role in the amelioration of age-associated vascular dysfunction by regular aerobic exercise.

[PubMed – as supplied by publisher]